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Physical Activity Predicts Microstructural Integrity in Memory-Related Networks in Very Old Adults

Identifieur interne : 001B23 ( Main/Exploration ); précédent : 001B22; suivant : 001B24

Physical Activity Predicts Microstructural Integrity in Memory-Related Networks in Very Old Adults

Auteurs : Qu Tian ; Kirk I. Erickson ; Eleanor M. Simonsick ; Howard J. Aizenstein ; Nancy W. Glynn ; Robert M. Boudreau ; Anne B. Newman ; Stephen B. Kritchevsky ; Kristine Yaffe ; Tamara B. Harris ; Caterina Rosano

Source :

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences [ 1079-5006 ] ; 2014.

RBID : PMC:4172036

Descripteurs français

KwdFr :
- Activité motrice, Femelle, Humains, Imagerie par tenseur de diffusion, Mâle, Mémoire, Substance blanche (anatomopathologie), Substance grise (anatomopathologie), Sujet âgé, Sujet âgé de 80 ans ou plus.
MESH :
- anatomopathologie : Substance blanche, Substance grise.
- Activité motrice, Femelle, Humains, Imagerie par tenseur de diffusion, Mâle, Mémoire, Sujet âgé, Sujet âgé de 80 ans ou plus.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Diffusion Tensor Imaging, Female, Gray Matter (pathology), Humans, Male, Memory, Motor Activity, White Matter (pathology).
MESH :
- pathology : Gray Matter, White Matter.
- Aged, Aged, 80 and over, Diffusion Tensor Imaging, Female, Humans, Male, Memory, Motor Activity.

Abstract

Background.

Although the beneficial effects of physical activity (PA) on memory and executive function are well established in older adults, little is known about the relationship between PA and brain microstructure and the contributions of physical functional limitations and chronic diseases. This study examined whether higher PA would be longitudinally associated with greater microstructural integrity in memory- and executive function-related networks and whether these associations would be independent of physical function and chronic diseases.

Methods.

Diffusion tensor imaging was obtained in 2006–2008 in 276 participants (mean age = 83.0 years, 58.7% female, 41.3% black) with PA (sedentary, lifestyle active, and exercise active) measured in 1997–1998. Gait speed, cognition, depressive symptoms, cardiovascular and pulmonary diseases, hypertension, stroke, and diabetes were measured at both time points. Mean diffusivity and fractional anisotropy were computed from normal-appearing gray and white matter in frontoparietal and subcortical networks. Moderating effects of physical function and chronic diseases were tested using hierarchical regression models.

Results.

Compared with the sedentary, the exercise active group had lower mean diffusivity in the medial temporal lobe and the cingulate cortex (β, p values: −.405, .023 and −.497, .006, respectively), independent of age, sex, and race. Associations remained independent of other variables, although they were attenuated after adjustment for diabetes. Associations between PA and other neuroimaging markers were not significant.

Conclusions.

Being exercise active predicts greater memory-related microstructural integrity in older adults. Future studies in older adults with diabetes are warranted to examine the neuroprotective effect of PA in these networks.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172036

DOI: 10.1093/gerona/glt287
PubMed: 24474004
PubMed Central: 4172036

Affiliations:

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Physical Activity Predicts Microstructural Integrity in Memory-Related Networks in Very Old Adults</title>
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,<addr-line>Bethesda, Maryland</addr-line>
.</nlm:aff>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Diffusion Tensor Imaging</term>
<term>Female</term>
<term>Gray Matter (pathology)</term>
<term>Humans</term>
<term>Male</term>
<term>Memory</term>
<term>Motor Activity</term>
<term>White Matter (pathology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Activité motrice</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par tenseur de diffusion</term>
<term>Mâle</term>
<term>Mémoire</term>
<term>Substance blanche (anatomopathologie)</term>
<term>Substance grise (anatomopathologie)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Substance blanche</term>
<term>Substance grise</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Gray Matter</term>
<term>White Matter</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Diffusion Tensor Imaging</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Memory</term>
<term>Motor Activity</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activité motrice</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par tenseur de diffusion</term>
<term>Mâle</term>
<term>Mémoire</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background.</title>
<p>Although the beneficial effects of physical activity (PA) on memory and executive function are well established in older adults, little is known about the relationship between PA and brain microstructure and the contributions of physical functional limitations and chronic diseases. This study examined whether higher PA would be longitudinally associated with greater microstructural integrity in memory- and executive function-related networks and whether these associations would be independent of physical function and chronic diseases.</p>
</sec>
<sec><title>Methods.</title>
<p>Diffusion tensor imaging was obtained in 2006–2008 in 276 participants (mean age = 83.0 years, 58.7% female, 41.3% black) with PA (sedentary, lifestyle active, and exercise active) measured in 1997–1998. Gait speed, cognition, depressive symptoms, cardiovascular and pulmonary diseases, hypertension, stroke, and diabetes were measured at both time points. Mean diffusivity and fractional anisotropy were computed from normal-appearing gray and white matter in frontoparietal and subcortical networks. Moderating effects of physical function and chronic diseases were tested using hierarchical regression models.</p>
</sec>
<sec><title>Results.</title>
<p>Compared with the sedentary, the exercise active group had lower mean diffusivity in the medial temporal lobe and the cingulate cortex (β, <italic>p</italic>
 values: −.405, .023 and −.497, .006, respectively), independent of age, sex, and race. Associations remained independent of other variables, although they were attenuated after adjustment for diabetes. Associations between PA and other neuroimaging markers were not significant.</p>
</sec>
<sec><title>Conclusions.</title>
<p>Being exercise active predicts greater memory-related microstructural integrity in older adults. Future studies in older adults with diabetes are warranted to examine the neuroprotective effect of PA in these networks.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Aizenstein, Howard J" sort="Aizenstein, Howard J" uniqKey="Aizenstein H" first="Howard J." last="Aizenstein">Howard J. Aizenstein</name>
<name sortKey="Boudreau, Robert M" sort="Boudreau, Robert M" uniqKey="Boudreau R" first="Robert M." last="Boudreau">Robert M. Boudreau</name>
<name sortKey="Erickson, Kirk I" sort="Erickson, Kirk I" uniqKey="Erickson K" first="Kirk I." last="Erickson">Kirk I. Erickson</name>
<name sortKey="Glynn, Nancy W" sort="Glynn, Nancy W" uniqKey="Glynn N" first="Nancy W." last="Glynn">Nancy W. Glynn</name>
<name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<name sortKey="Kritchevsky, Stephen B" sort="Kritchevsky, Stephen B" uniqKey="Kritchevsky S" first="Stephen B." last="Kritchevsky">Stephen B. Kritchevsky</name>
<name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name>
<name sortKey="Rosano, Caterina" sort="Rosano, Caterina" uniqKey="Rosano C" first="Caterina" last="Rosano">Caterina Rosano</name>
<name sortKey="Simonsick, Eleanor M" sort="Simonsick, Eleanor M" uniqKey="Simonsick E" first="Eleanor M." last="Simonsick">Eleanor M. Simonsick</name>
<name sortKey="Tian, Qu" sort="Tian, Qu" uniqKey="Tian Q" first="Qu" last="Tian">Qu Tian</name>
<name sortKey="Yaffe, Kristine" sort="Yaffe, Kristine" uniqKey="Yaffe K" first="Kristine" last="Yaffe">Kristine Yaffe</name>
</noCountry>
</tree>
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Physical Activity Predicts Microstructural Integrity in Memory-Related Networks in Very Old Adults

Physical Activity Predicts Microstructural Integrity in Memory-Related Networks in Very Old Adults

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur Pittsburgh
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